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Table 3 Composition of lung lining fluid in conducting airways and respiratory zone (from (Eixarch et al. 2010) and (Hastedt 2014))

From: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

 

Conducting airways

Respiratory Zone

Principal lining fluid

Mucus

Surfactant

Composition of fluid layer

1 % inorganic salts

85 % phospholipids

1 % proteins

5 % cholesterol

2 % glycoproteins (mucins)

10 % surfactant proteins (e.g., SP-A, SP-B, SP-C, SP-D)

1 % lipids

95 % water

Layer thickness

3–15 μm (decreases in thickness in lower airways)

~0.07 μm

Approximate volume

10–30 ml

7–20 ml