Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

AAPS Open

Table 5 Considerations for different organ target sites

GI Tract Considerations	Lung Considerations
SA of dose important (for disintegration)	Dose has large SA
Large SA for absorption	Large SA for dissolution/abs.
High Liquid volume	Low liquid volume
pH 1–8	pH 6–7
Rel. High hydrodynamic conditions	Rel. Low hydrodynamic conditions
	Macrophage interaction