From: Solid form changes during drug development: good, bad, and ugly case studies
pH | Buffer | k1 (hr−1) at 40 °C | t1/2 (days) at 40 °C |
---|---|---|---|
1 | 0.1 M HCl | 2.16 × 10−3 | 13 |
2 | 0.1 M maleate | 1.14 × 10−3 | 25 |
3 | 0.1 M citrate | 7.12 × 10−4 | 41 |
4 | 0.1 M citrate | 3.36 × 10−4 | 86 |
5 | 0.1 M citrate | 1.10 × 10−4 | 262 |
11 | 0.1 M carbonate (1/1 MeOH/H2O) | 1.23 × 10−3 | 23 |