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Table 1 pH Stability Data for Indinavir (used with permission from Ref (Crixivan Package Insert. (available at http://www.merck.com/product/usa/pi_circulars/c/crixivan/crixivan_pi.pdf. Accessed 2 March 2015))

From: Solid form changes during drug development: good, bad, and ugly case studies

pH

Buffer

k1 (hr−1) at 40 °C

t1/2 (days) at 40 °C

1

0.1 M HCl

2.16 × 10−3

13

2

0.1 M maleate

1.14 × 10−3

25

3

0.1 M citrate

7.12 × 10−4

41

4

0.1 M citrate

3.36 × 10−4

86

5

0.1 M citrate

1.10 × 10−4

262

11

0.1 M carbonate (1/1 MeOH/H2O)

1.23 × 10−3

23