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Table 7 ASAP data input for API 2 – dissolution at 20 min

From: Prediction of the changes in drug dissolution from an immediate-release tablet containing two active pharmaceutical ingredients using an accelerated stability assessment program (ASAPprime®)

Time (days)

T (°C)

%RH

%LC at 20 min

SD (%)

0

60

60

84.9

1.1

3

60

60

77.3

3

0

60

75

84.7

1.1

3

60

75

70.5

3

0

40

75

86.3

1.1

90

40

75

80.6

3

0

60

30

85.5

1.1

7

60

30

85.5

3

14

60

30

84.2

3

0

60

50

85.9

1.1

3

60

50

80

3

7

60

50

79.3

3

0

60

65

83.4

1.1

3

60

65

76

3

7

60

65

76.3

3

0

50

60

84.9

1.1

7

50

60

83.8

3

14

50

60

82.7

3

0

50

65

83.4

1.1

7

50

65

80.8

3

14

50

65

80.8

3