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Table 5 Stability parameters and R2 values determined by LNISO (11 data points) vs. LNISO (6 data points)

From: Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Compound #

LNISOa (11 data points)

LNISOa (6 data points)

Ea

(kcal/mol)

k(25)

(1/day)

R2

Ea

(kcal/mol)

k25

(1/day)

R2

A4

24.22 ± 0.88

6.58 ± 1.45E-4

0.99977

24.25 ± 1.94

6.49 ± 3.34E-4

0.99972

A7

27.68 ± 1.70

3.78 ± 1.61E-4

0.99966

27.80 ± 1.13

3.70 ± 1.04E-4

0.99994

A8

25.47 ± 1.18

1.32 ± 0.46E-5

0.99966

25.62 ± 2.61

1.26 ± 1.05E-5

0.99961

A11 b

14.14 ± 4.42

4.14 ± 6.05E-4

0.98775

12.69 ± 6.18

6.39 ± 16.17E-4

0.99341

A12

17.54 ± 1.43

3.02 ± 1.10E-3

0.99913

17.72 ± 2.64

2.86 ± 2.04E-3

0.99912

A13

25.26 ± 0.22

2.76 ± 0.17E-4

0.99998

25.20 ± 0.35

2.80 ± 0.27E-4

0.99999

A14

31.78 ± 0.42

4.33 ± 0.50E-5

0.99996

31.70 ± 0.96

4.40 ± 1.20E-5

0.99996

A15

31.91 ± 0.38

1.80 ± 0.20E-5

0.99996

31.87 ± 0.72

1.82 ± 0.38E-5

0.99998

A16 b

9.59 ± 2.82

3.94 ± 3.11E-4

0.99395

10.36 ± 3.79

3.27 ± 3.86E-4

0.99712

A17

27.05 ± 0.96

3.10 ± 0.90E-6

0.99969

26.91 ± 1.80

3.20 ± 1.80E-6

0.99982

  1. a LNISO Non-isothermal by Linear Heating
  2. bTwo compounds (A11 and A16), which didn’t follow the first order degradation kinetics
  3. R 2 Coefficient of Determination