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Table 6 Summary of the t 90% values and binning classifications predicted by the three methods described herein

From: Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Compound #

Description

LNISOa t90% (month)

CONV.b t90% (month)

Abbrev. t90% (month)

LNISOa Binning

CONV.b

Binning

Abbrev.c Binning

A1

Stable No Degradation

>24 months

>24 months

>24 months

BIN 1

BIN 1

BIN 1

A2

Stable No Degradation

>24 months

>24 months

>24 months

BIN 1

BIN 1

BIN 1

A3

Precipitation, Unstable:

Not Processed

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A4

First Order Degradation

5.3

7.4

6.5

BIN 3

BIN 3

BIN 3

A5

Stable No Degradation

>24 months

>24 months

>24 months

BIN 1

BIN 1

BIN 1

A6

Stable No Degradation

>24 months

>24 months

>24 months

BIN 1

BIN 1

BIN 1

A7

First Order Degradation

9.3

12.2

13.1

BIN 3

BIN 2

BIN 2

A8

Processed using degradant peak.

>24 months (266)

>24 months (210)

>24 months (163)

BIN 1

BIN 1

BIN 1

A9

Precipitation:

Not Processed

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 ---

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--- 

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A10

Stable No Degradation

>24 months

>24 months

>24 months

BIN 1

BIN 1

BIN 1

A11

Non First Order Kinetics

8.5

53.0

21.8

BIN 3

BIN 1

BIN 2

A12

First Order Degradation

1.2 

2.2 

1.7 

BIN 3

BIN 3

BIN 3

A13

First Order Degradation

12.7

15.2

14

BIN 2

BIN 2

BIN 2

A14

First Order Degradation

>24 months (81)

>24 months (135)

>24 months (130)

BIN 1

BIN 1

BIN 1

A15

First Order Degradation

>24 months (195)

>24 months (251)

>24 months (185)

BIN 1

BIN 1

BIN 1

A16

Non First Order Kinetics

8.9

41.8

41.3

BIN 3

BIN 1

BIN 1

A17

Processed using degradant peak.

>24 months (1136)

>24 months (1194)

>24 months (1929)

BIN 1

BIN 1

BIN 1

A18

Precipitation: Not Processed.

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  1. a LNISO Non-isothermal by Linear Heating
  2. b CONV. Conventional Isothermal
  3. c Abbrev. Abbreviated Isothermal