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Table 7 Summary of t98% values and binning classifications predicted by the three methods described herein

From: Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Compound #

Binning Classification

LNISOa t98% (month)

CONV.b t98% (month)

Abbrev.c t98% (month)

A1

Stable

>24 months

>24 months

>24 months

A2

Stable

>24 months

>24 months

>24 months

A3

Precipitation, Not Processed

 ---

--- 

 ---

A4

Unstable

1.0

1.4

1.2

A5

Stable

>24 months

>24 months

>24 months

A6

Stable

>24 months

>24 months

>24 months

A7

Unstable

1.8

2.3

2.5

A8

Stable

>24 months (51)

>24 months (40)

>24 months (31)

A9

Precipitation: Not Processed

 ---

--- 

 ---

A10

Stable

>24 months

>24 months

>24 months

A11

Unstable (Non-First Order Kinetics)

1.6

10.0

4.1

A12

Unstable

0.22

0.41

0.33

A13

Unstable

2.4

2.9

2.6

A14

Unstable by LNISO

15.3

>24 months (25.6)

>24 months (24.6)

A15

Stable

>24 months (37)

>24 months (47)

>24 months (35)

A16

Unstable (Non-First Order Kinetics)

1.7

7.9

7.8

A17

Stable

>24 months (215)

>24 months (226)

>24 months (365)

A18

Precipitation: Not Processed.

 ---

 ---

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  1. a LNISO Non-isothermal by Linear Heating
  2. b CONV. Conventional Isothermal
  3. c Abbrev. Abbreviated Isothermal