Table 3 Characterization and evaluation of 4 T1 CLENs loading efficiency
# | Nanoliposomes | mol% | Particle Size (nm) | Z-Potential (mV) | Dox Incorporation Efficiency % |
|---|---|---|---|---|---|
1 | 4 T1/chol | 100/0 | 131 ± 6.5 | − 14 ± 0.4 | 63 ± 1.3 |
2 | 4 T1/ chol | 90/10 | 184 ± 0.4 | − 20 ± 1.2 | 64 ± 1.9 |
3 | 4 T1/ chol | 75/25 | 239 ± 4.3 | −18 ± 2.50 | 86 ± 0.9 |
4 | 4 T1/ chol | 50/50 | 282 ± 0.3 | −20 ± 2.50 | 44 ± 0.9 |
5 | 4 T1/ chol /PEG-5000 | 73/25/2 | 180 ± 5.2 | −10 ± 1.2 | 81 ± 1.5 |
6 | 4 T1/ chol /PEG-5000 | 70/25/5 | 179 ± 0.2 | −13 ± 1.5 | 93 ± 0.9 |
7 | 4 T1/ chol /PEG-5000 | 65/25/10 | 290 ± 0.4 | −10 ± 1.7 | 41 ± 0.3 |
8 | DoxilLP | 45/50/5 | 168 ± 0.6 | −13 ± 1.5 | 95 ± 1.1 |