Fig. 11

Intact mass analysis of Pep-ADC by AP-LC-MS in non-human primates. Rhesus monkeys (n = 3) were dosed IV with a single 3 mg/kg Pep-ADC dose. Pep-ADC in dosed plasma samples at indicated time points was retrieved by pull-down for intact mass analysis on a Synapt G2S Q-TOF. Relative abundance of intact Pep-ADC and main metabolites (M1 and M2) is depicted by plotting average peak intensity for up to 14 days after dosing. Data plotted are mean peak intensity from three animals per time point. Error bars correspond to the S.D. calculated using GraphPad Prism 7. Error bars shorter than the symbols are not plotted