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Fig. 13 | AAPS Open

Fig. 13

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Fig. 13

In vivo stability of Pep-ADC (a) and unconjugated mAb3 (b). Shown are the fluorescence SEC-HPLC profiles of the DyLight650 labeled antibodies at indicated time points in plasma of C57BL/6 J mice after a single 3 mg/kg IV administration. The plasma samples were run on a BioSep-SEC-S3000 column at 1 mL/min elution rate with PBS as a mobile phase for 15 min

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