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Fig. 14 | AAPS Open

Fig. 14

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Fig. 14

Immunohistochemical analysis of cellular disposition of DyLight 650-labeled Pep-ADC (a and b) and Dylight 650-labeled unconjugated mAb3 (c and d). Tissue sections were stained with anti-DyLight 650 dye specific antibody. Asterisk (*) represents Pep-ADC localized to pancreatic Islets of Langerhans at Day 1. Arrowheads show labeling of capillaries with both antibodies

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