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Fig. 7 | AAPS Open

Fig. 7

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Fig. 7

Spleen and liver tissue to blood ratios of anti-CD74-Phos-Bud (a) and an unconjugated anti-CD74–011 (b) in wild type (WT) and human CD74+ transgenic (Tg) mice. Tissue/blood ratios were calculated from drug concentration measured by fluorescence emission-linked assay in blood and the tissues at 2 h, 6 h, 1 and 2 days after 5 mg/kg IV dosing. An additional 15 min time-point was collected for anti-CD74-Phos-Bud in Tg mice. Tissue/blood ratios greater than 1 are indicative of tissue uptake. Data plotted are mean from two mice per time point. Error bars correspond to the range. Error bars smaller than the symbol are not plotted

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