Skip to main content
AAPS Open

Table 1 Parameters in rats (n = 4) and monkeys (n = 2 female and 2 male) dosed with P-bi-TAT

From: Pharmacokinetics and biodistribution of a novel anticancer thyrointegrin αvβ3 antagonist: triazole modified tetraiodothyroacetic acid conjugated to polyethylene glycol (P-bi-TAT)

 

Rats

Monkeys, low dose†

Monkeys, high doseǂ

Dose proportionality ratio

Tmax (h)

6

6

7

-

Cmax (μg/mL)

225

222

727

3.3

M/F ratio, Cmax

-

1.1

1.0

-

T1/2 (h)

8.1

19.2

14.5

-

AUC (μg/mL*h)

3564

3649

11733

3.2

M/F ratio, AUC

-

1.2

1.3

-

  1. †Low dose, 25 mg/kg body weight
  2. ǂHigh dose, 82.5 mg/kg
  3. M/F ratio (AUC) = male/female
Back to article page