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Fig. 10 | AAPS Open

Fig. 10

From: Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections

Fig. 10

Yomesan-niclosamide dissolution as a function of Tris buffer pH: Maximum niclosamide concentrations from Fig. 9 (filled black circles) vs. supernatant pH, plotted along with pHp theory determined earlier (Needham 2022) (dotted black line), for anhydrous (AK Sci) niclosamide (pKa 7.12, Sw = 2.53 µM). Also shown are the day 2 equilibrated concentrations (gray-filled circles) and pHp theory for the monohydrate (dotted gray line) (Sw = 1 µM) (Sw = intrinsic solubility of the protonated niclosamide acid)

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