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Fig. 4 | AAPS Open

Fig. 4

From: Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections

Fig. 4

Dissolution of Yomesan-niclosamide equivalent in nominal pH 9.35 Tris buffers (0–180 min): A 300 µM, B 600 µM, and C 1 mM. White symbols signify the data points used for the logarithmic fit (dashed line) up to each peak time point of 180 min, 60 min, and 60 min respectively. Gray-filled symbols (B and C) represent a 2× dilution as the niclosamide concentration increased and approached the limit of detection for the UV-Vis absorbance detector. Error bars were ~ 1.5 µM and so within the filled symbols. The dotted line is to guide the eye and show the deviation from logarithmic

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