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Fig. 9 | AAPS Open

Fig. 9

From: Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections

Fig. 9

Dissolution of Yomesan-niclosamide equivalent in Tris pH buffers (0–180 min, black-filled symbols): A 300 µM, niclosamide nominal pH 7.41, final pH 7.31; B nominal pH 8.35 final pH 8.25; C nominal pH 8.85, final pH 8.77; D nominal pH 9.35, final pH 9.27 (B, C, D are at 600 µM niclosamide); White symbols signify the data points used for the logarithmic fit (dashed lines) up to each peak time point of 50 min, 50 min, 120 min, and 60 min, respectively. Gray-filled symbols (pH 9.35) represent a 2× dilution as the niclosamide concentration increased and approached the limit of detection for the UV-Vis absorbance detector. Error bars were ~ 1.5 µM and so within the filled symbols. The dotted line is to guide the eye and show the deviation from logarithmic. The day 2 concentration were 3 µM, 12.9 µM, 35.1 µM, and 112.3 µM (data not shown)

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