Skip to main content
AAPS Open
Fig. 8 | AAPS Open

Fig. 8

From: Strategies to stabilize dalbavancin in aqueous solutions: Section 4—identification of heat degradation products in 2-hydroxypropyl-β-cyclodextrin and divalent metal ion solutions at pH 4.5 and 7.0

Fig. 8

Molecular structures of a MAG, b DB-R2a, c DB-DP2b, d DB-Iso-DP2c, e DB-DP1d, and f DB-Iso-DP1e, produced by the thermal degradation of dalbavancin in acetate and phosphate-buffered solutions. (a. DB-R2 impurity was formed in Phosp10Cyclod110 and Phosp10Mg50Cyclod110 degraded samples. b. DB-DP2 (3S,4R,5R,6S)-6-{[(1S,2R,34S,37R,40R,52S)-5,32-dichloro-52-{[3-(dimethylamino)propyl]carbamoyl}-2,22,26,31,44,49-hexahydroxy-21,35,38,54,56,59-hexaoxo-47-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8(64),9,11,14,16,23(61),24,26,29(60),30,32,41(57),42,44,46,48,50,62,65-henicosaen-64-yl]oxy}-3,4-dihydroxy-5-(10-methylundecanamido)oxane-2-carboxylic acid. c. DB-Iso-DP2 (3S,4R,5R,6S)-6-{[(1S,2R,34R,37R,40R,52S)-5,32-dichloro-52-{[3-(dimethylamino)propyl]carbamoyl}-2,22,24,26,31,44,49-heptahydroxy-21,35,38,54,56,59-hexaoxo-47-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8(64),9,11,14,16,23(61),24,26,29(60),30,32,41(57),42,44,46,48,50,62,65-henicosaen-64-yl]oxy}-3,4-dihydroxy-5-(10-methylundecanamido)oxane-2-carboxylic acid. d. DB-DP1 (1S,2R,34S,37R,40R,52S)-5,32-dichloro-N-[3-(dimethylamino)propyl]-2,22,26,31,44,49,64-heptahydroxy-21,35,38,54,56,59-hexaoxo-47-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8(64),9,11,14,16,23(61),24,26,29(60),30,32,41(57),42,44,46,48,50,62,65-henicosaene-52-carboxamide. e. DB-Iso-DP1 (1S,2R,34R,37R,40R,52S)-5,32-dichloro-N-[3-(dimethylamino)propyl]-2,22,26,31,44,49,64-heptahydroxy-21,35,38,54,56,59-hexaoxo-47-{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.0.46,51]hexahexaconta-3,5,8(64),9,11,14,16,23(61),24,26,29(60),30,32,41(57),42,44,46,48,50,62,65-henicosaene-52-carboxamide)

Back to article page