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Fig. 9 | AAPS Open

Fig. 9

From: Strategies to stabilize dalbavancin in aqueous solutions: Section 4—identification of heat degradation products in 2-hydroxypropyl-β-cyclodextrin and divalent metal ion solutions at pH 4.5 and 7.0

Fig. 9

Dalbavancin recovery by LC–MS after 5 days at 70 °C in 10 mM acetate buffer (pH 4.5) with no ions, 10 mM Ca2+, 2 mM Mg2+, and 2 mM Zn2+ (blue bars); with 55 mM 2HPβCD and 0 mM or 10 mM Ca2+(green bars); and after 3 days at 70 °C in 10 mM phosphate buffer with 110 mM 2HPβCD and 0 mM or 50 mM Mg2+ (orange bars). The results are depicted as averages of three independent measurements ± SD

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