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Table 3 Summary of the observed degradation products of dalbavancin after stressing at 70 °C for 5 days in 10 mM acetate and 3 days in 10 mM phosphate buffer

From: Strategies to stabilize dalbavancin in aqueous solutions: Section 4—identification of heat degradation products in 2-hydroxypropyl-β-cyclodextrin and divalent metal ion solutions at pH 4.5 and 7.0

Compound no

RT (min)

m/z [M + H]+

Charge

Compound ID

1

4.25

1460.6

1 + 

Mannosyl aglycone (MAG)a

2

5.92

1447.32

1 + 

DB-Iso-DP1

3

6.20

1447.32

1 + 

DB-DP1

4

25.34

1817.7

1 + 

Dalbavancin (A1)a,b

4a

29.23

1817.7, 909.42

1 + , 2 + 

DB-R2a,c

5

41.60

1817.7, 909.51

1 + , 2 + 

Dalbavancin (B0)a,b

6

45.52

1817.7

1 + 

Dalbavancin (B1)a,b

7

49.84

1804.5

1 + 

DB-Iso-DP2

8

50.83

1804.5

1 + 

DB-DP2

  1. aIdentified by comparison with a standard
  2. bNot a degradation product: homolog of dalbavancin
  3. cOnly formed in the presence of 2HPβCD with or without Mg2+ in phosphate buffer at pH 7