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Table 6 The effect of 2HPβCD with and without Mg2+ on the yields of degradation products of dalbavancin found after stressing at 70 °C for 3 days in 10 mM phosphate buffer

From: Strategies to stabilize dalbavancin in aqueous solutions: Section 4—identification of heat degradation products in 2-hydroxypropyl-β-cyclodextrin and divalent metal ion solutions at pH 4.5 and 7.0

Compound ID

Relative EIC peak intensity (%)

Fraction of total HPLC-UV peak area

(%)

Phosp10Cyclod110

Phosp10Mg50Cyclod110

Phosp10

Phosp10Cyclod110

Phosp10Mg50Cyclod110

MAG

40

117

11.1

7.4

15.2

DB-Iso-DP1

135

142

1.9

2.4

2.4

DB-DP1

174

130

0.82

0.9

0.7

DB-R2

1267

240

0.74

6.6

1.7

DB-Iso-DP2

216

148

7.2

14.2

9.3

DB-DP2

268

146

1.8

3.3

2.0

Dalbavancin (B0)

70

97

64.1

45.9

60.2

Unknown degradants

None detected

None detected

7.0

16.9

5.6

Total degradants

N/A

N/A

30.6

51.7

36.2