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Table 3 IC50 and CI of SOG and ATO against HepG2 cells for different incubation time

From: PEGylated magnetic nanographene oxide for targeted delivery of arsenic trioxide and sec-o-glucosylhamaudol in tumor treatment with improved dual-drugs synergistic effect

Time

IC50 drug alone

(95% confidence interval)

IC50 drug combination

(95% confidence interval)

CI at IC50

SOG(µmol/L)

ATO(µmol/L)

SOG(µmol/L)

ATO(µmol/L)

 

24 h

1575.0 ± 59.5

52.0 ± 2.8

586.8 ± 33.0

17.8 ± 1.7

0.71

48 h

773.9 ± 36.6

19.9 ± 2.1

289.8 ± 27.2

9.9 ± 1.4

0.83

72 h

458.5 ± 18.5

14.2 ± 2.4

219.6 ± 16.1

6.9 ± 0.3

0.96