Fig. 2

Goodness-of-fit plots for a observation (DV) versus individual prediction (IPRED), b conditional weighted residue (CWRES) versus population prediction (PRED), and c conditional weighted residue (CWRES) versus time since the last dose. The solid red line represents LOWESS regression line, the solid black line the line of identity (a) or the zero line (b and c), and the area between dashed blue and red lines the 95^th and 99^th percentile interval, respectively (b and c)