Fig. 4

Visual predictive check of observations versus time since the last dose for apalutamide administration as whole tablets or applesauce. Whole tablets (left) and applesauce (right). The 2 dashed red lines represent the 5th and 95th percentiles of the observed apalutamide concentrations, while solid red line represents the 50th percentile of the observed apalutamide concentrations. The solid blue, gray, and blue shaded areas represent the 95% CI for the corresponding model-based predicted 5^th, 50^th, and 95^th percentiles computed for each bin across time and replicates, respectively. The blue shaded circles represent apalutamide observed plasma concentrations and the vertical lines at the top represent the time at where the bins were performed