Fig. 5

Numeric predictive check showing the predictive performance of the applesauce covariates for central tendency of relative apalutamide C_max and AUC_0–168 h. The histogram represents the distribution of the geometric mean ratios across the 1000 simulated studies. The solid black lines (dashed black lines) represent the mean ratio (5 and 95% percentile) across the simulated studies. The solid red vertical line indicates the observed GMR from the statistical analysis of study NCT03802682 PK parameters