Table 2 Optimized IVRT parameters (Wellington 2023)
VDC system | 6-cell diffusion manual apparatus (Hanson) |
|---|---|
Cell orifice | 15 mm |
Cell capacity (volume) | 7.9 mL |
Temperature | 32 ± 1 °C |
Receptor medium | Phosphate buffer and ethanol (50:50% v/v) |
Synthetic membranes | PES (0.45 μm, 25 mm, pre-soaked in receptor medium) |
Dose | 300 mg |
Stirring speed | 600 ± 60 rpm |
Sampling volume | 200 µL |
Sampling interval | 0.5, 1, 2, 3, 4, 5, and 6 h |