Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

AAPS Open

Table 1 Particle size distribution data

Material ID	Note	Particle size (µm)			Span
Material ID	Note	D₁₀	D₅₀	D₉₀	Span
Starting material	MET	41.4	83.8	144	1.2
1012–88-1	M-CPT (unmilled)	600	893	1420	0.9
1012–111-1	M-CPT (milled)	308	461	680	0.8