Skip to main content

Table 1 Pharmacokinetic evaluation of Palladone XL™ after co-ingestion of alcohol in fasted state (data from reference (FDA 2005a))

From: A review of in vivo and in vitro aspects of alcohol-induced dose dumping

Parameter

Ratio 4

Ratio 20

Ratio 40

Cmax

Mean

1

2

6

Range

1–2

1–6

1–16

AUC

Mean

1

1

1.3

Range

0.5–1.9

0.4–1.5

0.6–3.4