Table 5 Influence of ethanol on the relative saturated solubility of three drugs in different media (data from reference (Levina et al. 2007))
From: A review of in vivo and in vitro aspects of alcohol-induced dose dumping
Drug | % ethanol in water | % ethanol in phosphate buffer pH 6.5 (with 1% SLS) | ||
|---|---|---|---|---|
5% | 40% | 5% | 40% | |
felodipine | 2.5 | 1245 | 0.89 | 5.39 |
gliclazide | 12 | 11.18 | - | - |
metformin HCl | 0.84 | 0.66 | - | - |