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Fig. 3 | AAPS Open

Fig. 3

From: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

Fig. 3

Cellular and non-cellular barriers of the lung: after landing on lung lining fluids (1) the drug must cross the pulmonary epithelium (2) in order to reach the underlying tissue or the systemic circulation, respectively, and must also overcome clearance processes (3) mucociliary clearance in the airways and the clearance by macrophage in the deep lung (de Souza et al. 2014), Modified with permission from (Ruge et al. 2013)

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