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Table 4 Impact of solubility on mean dissolution time of inhaled corticosteroids

From: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

Drug

CS (μg/ml)

Do

Mean Dissolution Time (hr)

Fluticasone propionate

0.14

27

>8

Beclomethasone dipropionate

0.13

15

>5

Budesonide

16

0.375

~0.1

Flunisolide

140

0.01

<0.03