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Table 5 Considerations for different organ target sites

From: Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

GI Tract Considerations Lung Considerations
SA of dose important (for disintegration) Dose has large SA
Large SA for absorption Large SA for dissolution/abs.
High Liquid volume Low liquid volume
pH 1–8 pH 6–7
Rel. High hydrodynamic conditions Rel. Low hydrodynamic conditions
  Macrophage interaction