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Table 1 pH Stability Data for Indinavir (used with permission from Ref (Crixivan Package Insert. (available at http://www.merck.com/product/usa/pi_circulars/c/crixivan/crixivan_pi.pdf. Accessed 2 March 2015))

From: Solid form changes during drug development: good, bad, and ugly case studies

pH Buffer k1 (hr−1) at 40 °C t1/2 (days) at 40 °C
1 0.1 M HCl 2.16 × 10−3 13
2 0.1 M maleate 1.14 × 10−3 25
3 0.1 M citrate 7.12 × 10−4 41
4 0.1 M citrate 3.36 × 10−4 86
5 0.1 M citrate 1.10 × 10−4 262
11 0.1 M carbonate (1/1 MeOH/H2O) 1.23 × 10−3 23