Skip to main content

Table 2 Examples of Excipients Inhibiting In Vitro/In Vivo Metabolic Enzymes and Membrane Transporters (Chen 2008; Constantinides et al. 2007)

From: Considerations and recommendations on traditional and non-traditional uses of excipients in oral drug products

Excipient

CYP3A

P-gp

C8–C20 fatty acid glycerol and PEG esters: Cremophor EL and RH40, Solutol HS-15, Labrasol, Softigen 767, Aconnon E

-

+

Sodium Caprate

-

+

Polysorbates : Tween 80, Tween 20

+

+

Sucrose esters : sucrose monolaurate

-

+

Tocol esters : TPGS

-

+

PEG 300/400

-

+

Triton X-100

-

+

Pluronic block copolymer (Pluronic F68)

+

+

Amphiphilic diblock copolymers (Me-PEG-b-PCL)

-

+

Peppermint Oil

+

-