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Table 3 Comparison of stability parameters for acetaminophen and sulfacetamide obtained by non-isothermal method vs. isothermal method in the literature (Koshy and Lach 1961; Meakin et al. 1971)

From: Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Model Compound Conventional Isothermal Method (Literature)a Non-isothermal Methodb
Acetaminophen (pH 3.0) k 25 = 3.27 · 10−4 day−1
E a = 18.0 kcal/mol
k 25 = 7.92 · 10−5 (±1.54 · 10−6) day−1
E a = 19.5 (±0.7) kcal/mol
Sulfacetamide (pH 7.4) k 25 = 6.83 · 10−5 day−1
E a = 22.9 kcal/mol
k 25 = 2.38 · 10−5 (±3.12 · 10−7) day−1
E a = 25.0 (±0.4) kcal/mol
  1. aIsothermal stability data in Ref. (Koshy and Lach 1961; Meakin et al. 1971), where the reported k values were extrapolated to 25 °C by using Arrhenius plots
  2. bNon-isothermal by Linear Heating (LNISO)