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Table 5 Stability parameters and R2 values determined by LNISO (11 data points) vs. LNISO (6 data points)

From: Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Compound # LNISOa (11 data points) LNISOa (6 data points)
Ea
(kcal/mol)
k(25)
(1/day)
R2 Ea
(kcal/mol)
k25
(1/day)
R2
A4 24.22 ± 0.88 6.58 ± 1.45E-4 0.99977 24.25 ± 1.94 6.49 ± 3.34E-4 0.99972
A7 27.68 ± 1.70 3.78 ± 1.61E-4 0.99966 27.80 ± 1.13 3.70 ± 1.04E-4 0.99994
A8 25.47 ± 1.18 1.32 ± 0.46E-5 0.99966 25.62 ± 2.61 1.26 ± 1.05E-5 0.99961
A11 b 14.14 ± 4.42 4.14 ± 6.05E-4 0.98775 12.69 ± 6.18 6.39 ± 16.17E-4 0.99341
A12 17.54 ± 1.43 3.02 ± 1.10E-3 0.99913 17.72 ± 2.64 2.86 ± 2.04E-3 0.99912
A13 25.26 ± 0.22 2.76 ± 0.17E-4 0.99998 25.20 ± 0.35 2.80 ± 0.27E-4 0.99999
A14 31.78 ± 0.42 4.33 ± 0.50E-5 0.99996 31.70 ± 0.96 4.40 ± 1.20E-5 0.99996
A15 31.91 ± 0.38 1.80 ± 0.20E-5 0.99996 31.87 ± 0.72 1.82 ± 0.38E-5 0.99998
A16 b 9.59 ± 2.82 3.94 ± 3.11E-4 0.99395 10.36 ± 3.79 3.27 ± 3.86E-4 0.99712
A17 27.05 ± 0.96 3.10 ± 0.90E-6 0.99969 26.91 ± 1.80 3.20 ± 1.80E-6 0.99982
  1. a LNISO Non-isothermal by Linear Heating
  2. bTwo compounds (A11 and A16), which didn’t follow the first order degradation kinetics
  3. R 2 Coefficient of Determination