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Table 6 Summary of the t 90% values and binning classifications predicted by the three methods described herein

From: Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Compound # Description LNISOa t90% (month) CONV.b t90% (month) Abbrev. t90% (month) LNISOa Binning CONV.b
Binning
Abbrev.c Binning
A1 Stable No Degradation >24 months >24 months >24 months BIN 1 BIN 1 BIN 1
A2 Stable No Degradation >24 months >24 months >24 months BIN 1 BIN 1 BIN 1
A3 Precipitation, Unstable:
Not Processed
 --- ---   --- ---  ---  --- 
A4 First Order Degradation 5.3 7.4 6.5 BIN 3 BIN 3 BIN 3
A5 Stable No Degradation >24 months >24 months >24 months BIN 1 BIN 1 BIN 1
A6 Stable No Degradation >24 months >24 months >24 months BIN 1 BIN 1 BIN 1
A7 First Order Degradation 9.3 12.2 13.1 BIN 3 BIN 2 BIN 2
A8 Processed using degradant peak. >24 months (266) >24 months (210) >24 months (163) BIN 1 BIN 1 BIN 1
A9 Precipitation:
Not Processed
 --- ---   --- ---  ---  --- 
A10 Stable No Degradation >24 months >24 months >24 months BIN 1 BIN 1 BIN 1
A11 Non First Order Kinetics 8.5 53.0 21.8 BIN 3 BIN 1 BIN 2
A12 First Order Degradation 1.2  2.2  1.7  BIN 3 BIN 3 BIN 3
A13 First Order Degradation 12.7 15.2 14 BIN 2 BIN 2 BIN 2
A14 First Order Degradation >24 months (81) >24 months (135) >24 months (130) BIN 1 BIN 1 BIN 1
A15 First Order Degradation >24 months (195) >24 months (251) >24 months (185) BIN 1 BIN 1 BIN 1
A16 Non First Order Kinetics 8.9 41.8 41.3 BIN 3 BIN 1 BIN 1
A17 Processed using degradant peak. >24 months (1136) >24 months (1194) >24 months (1929) BIN 1 BIN 1 BIN 1
A18 Precipitation: Not Processed.  ---  --- --- --- --- ---
  1. a LNISO Non-isothermal by Linear Heating
  2. b CONV. Conventional Isothermal
  3. c Abbrev. Abbreviated Isothermal