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Table 9 Stability of candesartan cilexetil optimum nanoemulsion formula (NE-4)

From: Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Test

Results at temperature 40 °C

Initial value

After 1 month

After 3 months

Droplet size (nm)

22.1

22.7

24.6

PDI

0.229

0.275

0.241

Zeta potential (mV)

−120.82

−115.68

−104.38

Transmittance %

99.8433 ± 0.2081

99.7333 ± 0.1527

98.6000 ± 0.1000

pH

5.0966 ± 0.2630

5.0666 ± 0.0585

5.0533 ± 0.0208

RI

1.3931 ± 0.0013

1.3783 ± 0.0003

1.3728 ± 0.0004

Surface tension (mN/m)

45.31

44.33

44.28

Conductivity(μs/cm)

181.0666

181.1333 ± 0.2854

181.1666 ± 0.3055

Viscosity(mPa.s)

23.0333 ± 1527

22.9333 ± 0.6658

22.5666 ± 0.9609

Dissolution

99.6652 ± 0.3226

99.4279 ± 0.0572

98.1649 ± 0.0002