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Table 3 Ratios and 90% Geometric Confidence Intervals

From: A randomized, open-label study assessing the bioequivalence of two formulations of Fingolimod 0.5 mg in healthy subjects

Parameter

Treatment Comparisons

Ratioa

90% Geometric CIb

Intra-subject CV

Inter-subject CV

Lower

Upper

AUC0–72

Test vs Reference

99.15%

95.88%

102.52%

4.53%

9.96%

Cmax

Test vs Reference

98.58%

94.61%

102.72%

5.56%

11.35%

  1. AUC 0–72 area under the concentration–time curve from time 0 to hour 72, C max maximum concentration, CV coefficient of variation
  2. aCalculated using least-squares means according to the formula: e(difference) × 100
  3. b90% geometric confidence interval (CI) using ln-transformed data
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