Fig. 13From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selectionIn vivo stability of Pep-ADC (a) and unconjugated mAb3 (b). Shown are the fluorescence SEC-HPLC profiles of the DyLight650 labeled antibodies at indicated time points in plasma of C57BL/6Â J mice after a single 3Â mg/kg IV administration. The plasma samples were run on a BioSep-SEC-S3000 column at 1Â mL/min elution rate with PBS as a mobile phase for 15Â minBack to article page