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Fig. 8 | AAPS Open

Fig. 8

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Fig. 8

The concentration time profile of Pep-ADC measured by two different assays. Plasma samples were collected at multiple time points over 14 days from mice IV dosed with 10 mg/kg of Pep-ADC, and measured for intact antibody concentrations by MSD assay (Total mAb3 assay) as well as bioactive ADC using a cell-based assay (Bioassay). Data plotted are mean from 3 mice. Error bars correspond to the S.D. calculated using GraphPad Prism 7. Error bars shorter than the symbols are not plotted

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