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Table 1 PK parameters following IV administration of anti-CD74 to C57BL/6 J mice

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Dose

(mg/kg)

t1/2

(day)

Cmax

(μg/mL)

CL

(mL/day/kg)

Vss

(mL/kg)

AUC0-INF

(day*μg/mL)

10

3.75

90.0

195

589

51.4

3

3.42

27.8

70.3

295

42.7

1

3.90

12.0

39.8

197

25.2

0.3

3.97

2.72

31.5

170

9.52

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