Skip to main content

Table 1 PK parameters following IV administration of anti-CD74 to C57BL/6 J mice

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Dose
(mg/kg)
t1/2
(day)
Cmax
(μg/mL)
CL
(mL/day/kg)
Vss
(mL/kg)
AUC0-INF
(day*μg/mL)
10 3.75 90.0 195 589 51.4
3 3.42 27.8 70.3 295 42.7
1 3.90 12.0 39.8 197 25.2
0.3 3.97 2.72 31.5 170 9.52