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Table 2 Pharmacokinetic parameters following IV administration of Pep-ADC to C57BL/6 J mice

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Assay

Dose

(mg/kg)

t1/2

(day)

AUC0–14

(day*μg/mL)

CL

(mL/day/kg)

Vss

(mL/kg)

Total mAb3

1

5.12

56.9

15.5

89.1

10

4.76

657

13.9

69.0

Bioassay

1

2.55

28.5

34.9

49.3

10

2.78

264

37.5

64.7

  1. AUC0–14: Area under the curve from zero to 14 days; CL: Clearance; t1/2: Terminal half-life; Vss: Volume of distribution at steady state