From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection
Assay
Dose
(mg/kg)
t1/2
(day)
AUC0–14
(day*μg/mL)
CL
(mL/day/kg)
Vss
(mL/kg)
Total mAb3
1
5.12
56.9
15.5
89.1
10
4.76
657
13.9
69.0
Bioassay
2.55
28.5
34.9
49.3
2.78
264
37.5
64.7