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Table 2 Pharmacokinetic parameters following IV administration of Pep-ADC to C57BL/6 J mice

From: Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

Assay Dose
(mg/kg)
t1/2
(day)
AUC0–14
(day*μg/mL)
CL
(mL/day/kg)
Vss
(mL/kg)
Total mAb3 1 5.12 56.9 15.5 89.1
10 4.76 657 13.9 69.0
Bioassay 1 2.55 28.5 34.9 49.3
10 2.78 264 37.5 64.7
  1. AUC0–14: Area under the curve from zero to 14 days; CL: Clearance; t1/2: Terminal half-life; Vss: Volume of distribution at steady state