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Table 5 In vitro release studies of reconstituted formulation F8 on day 1, 2, 3 and 7 of reconstitution

From: Development and evaluation of taste masked dry syrup formulation of potassium chloride

% Cumulative release

 

0.1 N HCl

pH 6.8 Phosphate buffera

Time(min)

1st day

2nd day

3rd day

7th day

1st day

2nd day

3rd day

7th day

5

56.6 ± 0.3

57.1 ± 0.2

56.1 ± 0.2

73.0 ± 0.3

2.8 ± 0.5

5.6 ± 0.2

6.8 ± 0.9

10.3 ± 0.2

10

67.0 ± 0.8

66.4 ± 0.3

65.0 ± 0.5

82.9 ± 0.2

5.65 ± 0.2

6.9 ± 0.3

7.7 ± 0.2

12.3 ± 0.3

15

83.4 ± 0.3

80.5 ± 0.6

81.0 ± 0.3

96.9 ± 0.1

8.48 ± 0.4

8.5 ± 0.8

8.2 ± 0.2

15.8 ± 0.2

30

98.4 ± 0.1

95.4 ± 0.1

94.3 ± 0.2

99.8 ± 0.3

13.6 ± 2.9

13.8 ± 0.4

15.9 ± 2.6

20.3 ± 1.2

  1. alower drug release in pH 6.8 Phosphate buffer indicates better efficiency of coating of KCl with Eudragit E 100 and hence better taste masking. All the values are average ± standard deviation of n = 6