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Table 5 In vitro release studies of reconstituted formulation F8 on day 1, 2, 3 and 7 of reconstitution

From: Development and evaluation of taste masked dry syrup formulation of potassium chloride

% Cumulative release
  0.1 N HCl pH 6.8 Phosphate buffera
Time(min) 1st day 2nd day 3rd day 7th day 1st day 2nd day 3rd day 7th day
5 56.6 ± 0.3 57.1 ± 0.2 56.1 ± 0.2 73.0 ± 0.3 2.8 ± 0.5 5.6 ± 0.2 6.8 ± 0.9 10.3 ± 0.2
10 67.0 ± 0.8 66.4 ± 0.3 65.0 ± 0.5 82.9 ± 0.2 5.65 ± 0.2 6.9 ± 0.3 7.7 ± 0.2 12.3 ± 0.3
15 83.4 ± 0.3 80.5 ± 0.6 81.0 ± 0.3 96.9 ± 0.1 8.48 ± 0.4 8.5 ± 0.8 8.2 ± 0.2 15.8 ± 0.2
30 98.4 ± 0.1 95.4 ± 0.1 94.3 ± 0.2 99.8 ± 0.3 13.6 ± 2.9 13.8 ± 0.4 15.9 ± 2.6 20.3 ± 1.2
  1. alower drug release in pH 6.8 Phosphate buffer indicates better efficiency of coating of KCl with Eudragit E 100 and hence better taste masking. All the values are average ± standard deviation of n = 6