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Table 2 Applications and capital costs of different screening technologies by technique or equipment

From: Substandard and falsified medicine screening technologies

Screening Technology Techniques and Notable Equipment

Applicationa

Price Range (USD)b

I

II

III

IV

V

VI

Infrared spectroscopy

NA

+

NA

+N

NA

NA

$25,000 - $70,000

Near infrared spectroscopy

NA

+

NA

+N

NA

NA

$7000 - $60,000

Raman spectrometry

NA

+

NA

+N

NA

NA

$18,000 - $60,000

X-ray diffraction spectroscopy

NA

+ L

NA

NA

NA

NA

information not obtained

X-ray fluorescence spectroscopy

NA

+

+ L

+ L

+ L

NA

$30,000 - $60,000

Ion mobility spectrometry

NA

+

+

+L

+L

NA

$25,000 - $60,000

CD5 – multi-spectral imaging

+

NA

NA

NA

NA

NA

Not commercially available

Counterfeit Drug Identifier – multi-wavelength absorption

NA

+

NA

NA

NA

NA

$100 but not commercially available

GPHF Minilab™ – chromatography and disintegration

NA

+

+ L

+ L

NA

+

$4500 - $10,000

Paper analytical device – chromatography and wet chemistry

NA

+

NA

+ L

NA

NA

$1 per test card

PharmaChk – chemiluminescence

NA

NA

NA

+N

NA

NA

Not commercially available

Speedy Breedy – respirometry (sterility)

NA

NA

+ L

NA

+N

NA

$4500 - $5000

  1. (+) Intended application
  2. (+N) Intended but non-routine application
  3. (+L) Intended application with significant limitations e.g., able to analyze a limited number of drug substances
  4. (NA) Not an intended application
  5. aAs per proposed USP General Chapter < 1850>
  6. bRanges reflect price quotes obtained from instrument vendors and information from the literature.