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Table 1 Parameters in rats (n = 4) and monkeys (n = 2 female and 2 male) dosed with P-bi-TAT

From: Pharmacokinetics and biodistribution of a novel anticancer thyrointegrin αvβ3 antagonist: triazole modified tetraiodothyroacetic acid conjugated to polyethylene glycol (P-bi-TAT)

  Rats Monkeys, low dose Monkeys, high doseǂ Dose proportionality ratio
Tmax (h) 6 6 7 -
Cmax (μg/mL) 225 222 727 3.3
M/F ratio, Cmax - 1.1 1.0 -
T1/2 (h) 8.1 19.2 14.5 -
AUC (μg/mL*h) 3564 3649 11733 3.2
M/F ratio, AUC - 1.2 1.3 -
  1. Low dose, 25 mg/kg body weight
  2. ǂHigh dose, 82.5 mg/kg
  3. M/F ratio (AUC) = male/female