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Table 4 Predicted results and confidence intervals for the selected responses of the optimized method

From: Perspectives in modeling and model validation during analytical quality by design chromatographic method evaluation: a case study

Response Goal Predicted result Desirability − 2 Sigma conf. limit + 2 Sigma conf. limit
No. of peaks Maximize 8.0 1.0000 6.3 10.5
No. of peaks ≥ 1.5 — USP resolution Maximize 6.2 1.0000 4.8 9.5
Max peak 1 – USP plate count Maximize 20,313 1.0000 17,560 23,067
Max peak 1 — USP plate count — Cpk Maximize 2.01 1.0000 1.78 2.24
No. of peaks ≥ 1.5 — USP resolution — Cpk Maximize 3.59 1.0000 3.54 3.63