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Fig. 2 | AAPS Open

Fig. 2

From: A competitive ligand-binding assay for the detection of neutralizing antibodies against dostarlimab (TSR-042)

Fig. 2

Drug removal procedure. a Acidification of serum solution containing drug-NAb complexes with 1 M acetic acid separates the drug from the drug-NAb complex. b Free drug is captured by PD-1–biotin that is bound to streptavidin magnetic Dynabeads, allowing the free NAb to be detected in the NAb detection assay. NAb, neutralizing antibody; PD-1, programmed death 1

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