A competitive ligand-binding assay for the detection of neutralizing antibodies against dostarlimab (TSR-042)

AAPS Open

Table 1 Assay sensitivity

Run ID	CP corresponding concentration (ng/mL)^a
Run 4	387.9
Run 6	366.2
Run 9	431.0
Run 10	221.4
Run 11	289.8
Mean	339.3
SD	83.4
Sensitivity	476.5^b

CP cut point, SD standard deviation
^aRegression model: 5PL (auto) with weighting factor of 1/F^{^}2
^bSensitivity was calculated using “average concentration + t 0.05, Z (one side) × SD”