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Table 5 Drug interference

From: A competitive ligand-binding assay for the detection of neutralizing antibodies against dostarlimab (TSR-042)

TSR-022 (μg/mL)

NAb spiked at LPC level

NAb unspiked

ECL

%CV

Plate CP

Condition

ECL

%CV

Plate CP

Condition

1350

14676

7.4

2484.5

> CP

2253

10.1

2484.5

< CP

450

11298

12.7

2484.5

> CP

2070

6.1

2484.5

< CP

150

11444

8.8

2484.5

> CP

1962

8.5

2484.5

< CP

0

13930

8.1

2484.5

> CP

2391

10.8

2484.5

< CP

  1. CP cut point, %CV coefficient of variation, ECL electrochemiluminescence readout, LPC low-positive control, NAb neutralizing antibody