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Table 3 Frequency of values above and below cut point estimates following outlier removal

From: A bridging assay for detection and characterization of anti-drug antibodies to dostarlimab, a new anti-PD-1 therapeutic monoclonal antibody

Type

Error rate

Cut point

Above

% Above

Below

% Below

Frequency of S/N ratio values above and below the screening cut point estimates following outlier removal

Parametric

5%

1.02

27

11.34

211

88.66

Nonparametric

5%

1.11

11

4.62

227

95.38

Frequency of percent inhibition values above and below the confirmatory cut point estimates following outlier removal

Parametric

1%

36.54

10

3.91

246

96.09

Nonparametric

1%

40.73

2

0.78

254

99.22